Doxycycline: here's the fair price
Start with the lowest cash price you can pay for doxycycline and how to get it. Below that is what pharmacies pay, so you can tell a fair quote from a high one.
Doxycycline Hyclate 20 mg Tab
A fair cash price is usually this cost plus a dispensing fee. If your quote is many times higher, ask about a generic, another pharmacy, or a cash discount.
Ask for generic Doxycycline Hyclate 20 mg Tab. Pharmacies pay about $3.13 for 30. Ask your pharmacy for its cash price and compare it with your copay. A fair cash price is close to this cost plus a dispensing fee.
Source: CMS NADAC weekly file, updated 2026-11-03. Ask your prescriber or pharmacist whether a generic is right for you.
Source: CMS NADAC weekly file updated 2026-11-03. Median across NDCs with the same description. Public domain.
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Every strength and form
| Product | Pharmacy cost | 30 count | Effective |
|---|---|---|---|
| DOXYCYCLINE HYCLATE 20 MG TABGeneric | $0.10 per tablet or capsule | $3.13 | 10/21/2026 |
| DOXYCYCLINE HYCLATE 100 MG CAPGeneric | $0.11 per tablet or capsule | $3.24 | 10/21/2026 |
| DOXYCYCLINE HYCLATE 100 MG TABGeneric | $0.12 per tablet or capsule | $3.60 | 10/21/2026 |
| DOXYCYCLINE MONO 50 MG CAPGeneric | $0.15 per tablet or capsule | $4.42 | 10/21/2026 |
| DOXYCYCLINE HYCLATE 50 MG CAPGeneric | $0.15 per tablet or capsule | $4.49 | 10/21/2026 |
| DOXYCYCLINE MONO 50 MG TABLETGeneric | $0.16 per tablet or capsule | $4.72 | 10/21/2026 |
| DOXYCYCLINE MONO 100 MG CAPGeneric | $0.22 per tablet or capsule | $6.73 | 10/21/2026 |
| DOXYCYCLINE 25 MG/5 ML SUSPGeneric | $0.23 per mL | n/a | 10/21/2026 |
| DOXYCYCLINE MONO 100 MG TABLETGeneric | $0.26 per tablet or capsule | $7.73 | 10/21/2026 |
| DOXYCYCLINE MONO 75 MG TABLETGeneric | $0.29 per tablet or capsule | $8.85 | 10/21/2026 |
| DOXYCYCLINE HYCLATE 75 MG TABGeneric | $0.55 per tablet or capsule | $16.45 | 10/21/2026 |
| DOXYCYCLINE MONO 150 MG TABLETGeneric | $0.60 per tablet or capsule | $18.05 | 10/21/2026 |
| DOXYCYCLINE HYCLATE 150 MG TABGeneric | $0.72 per tablet or capsule | $21.51 | 10/21/2026 |
| DOXYCYCLINE HYC DR 50 MG TABGeneric | $1.57 per tablet or capsule | $47.08 | 04/22/2026 |
| DOXYCYCLINE HYC DR 100 MG TABGeneric | $2.16 per tablet or capsule | $64.93 | 10/21/2026 |
| DOXYCYCLINE 50 MG TABLETGeneric | $4.39 per tablet or capsule | $131.79 | 10/21/2026 |
| DOXYCYCLINE IR-DR 40 MG CAPGeneric | $4.86 per tablet or capsule | $145.70 | 10/21/2026 |
| DOXYCYCLINE HYC DR 200 MG TABGeneric | $5.89 per tablet or capsule | $176.69 | 10/21/2026 |
Source: CMS NADAC weekly file, updated 2026-11-03. National average acquisition cost, not a retail quote.
Three questions that save money on Doxycycline
- Is there a generic? It is often the same medicine for much less.
- What is your cash price? Compare it with your copay before you pay.
- Is a 90 day supply cheaper? It often costs less per pill.
About this medicine
In plain words
Your pharmacist can tell you what this medicine is for, how to take it, and what to watch for. Ask them about cost too. The notes below come from the official FDA label. We changed hard medical words to everyday ones.
What it is used for
INDICATIONS AND USAGE To reduce the development of drug-resistant bacteria and maintain effectiveness of doxycycline and other antibacterial drugs, doxycycline should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Treatment: Doxycycline is used for the treatment of the following infections: Rocky Mountain spotted fever, typhus fever and the typhus group, Q...
Side effects people mention most
side effects Due to oral doxycycline's virtually complete absorption, side effects of the lower bowel, particularly diarrhea, have been infrequent. The following side effects have been observed in patients receiving tetracyclines: Gastrointestinal: anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, inflammatory lesions (with monilial overgrowth) in the anogenital region, and pancreatitis. Hepatotoxicity has been reported rarely. These reactions have been caused by both the oral and parenteral administration of tetracyclines. Superficial discoloration of the...
Other medicines and foods to ask about
Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin. Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations. Absorption of tetracyclines is impaired by bismuth subsalicylate. Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. The concurrent use of tetracycline and Penthrane ®...
Important warnings
WARNINGS The use of drugs of the tetracycline class during tooth development (last half of pregnancy, infancy and childhood to the age of 8 years) may cause permanent discoloration of the teeth (yellow-gray-brown). This adverse reaction is more common during long-term use of the drugs, but it has been observed following repeated short-term courses. Enamel hypoplasia has also been reported. Use doxycycline in child patients 8 years of age or less only when the potential benefits are expected to outweigh the risks in severe or life-threatening conditions (e.g., anthrax, Rocky Mountain spotted fever), particularly when there are no alternative therapies. Clostridium difficile associated...
Source: FDA drug label via openFDA, label effective 2026-05-01. Full label on DailyMed. Excerpts are shortened, with section numbers removed and some medical words changed to plain words. Read the full label and ask your pharmacist.
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How we pick these: same FDA drug class where known, then nearby medicines. Our editorial and data methods.