Doxepin: here's the fair price
This is what US pharmacies pay, on average, for doxepin. Use it to spot a fair cash price, and feel good about asking for one.
Doxepin 10 Mg Capsule
A fair cash price is usually this cost plus a dispensing fee. If your quote is many times higher, ask about a generic, another pharmacy, or a cash discount.
Ask for generic Doxepin 10 Mg Capsule. Pharmacies pay about $2.39 for 30. Ask your pharmacy for its cash price and compare it with your copay. A fair cash price is close to this cost plus a dispensing fee.
Source: CMS NADAC as of 2026-11-04. Ask your prescriber or pharmacist whether a generic is right for you.
Source: CMS NADAC weekly file as of 2026-11-04. Median across NDCs with the same description. Public domain.
Your ZIP and location stay in your browser. We never store them.
Every strength and form
| Product | Pharmacy cost | 30 count | Effective |
|---|---|---|---|
| DOXEPIN 10 MG CAPSULEGeneric | $0.08 per tablet or capsule | $2.39 | 10/21/2026 |
| DOXEPIN 25 MG CAPSULEGeneric | $0.15 per tablet or capsule | $4.43 | 10/21/2026 |
| DOXEPIN 50 MG CAPSULEGeneric | $0.16 per tablet or capsule | $4.92 | 10/21/2026 |
| DOXEPIN 75 MG CAPSULEGeneric | $0.22 per tablet or capsule | $6.71 | 10/21/2026 |
| DOXEPIN 100 MG CAPSULEGeneric | $0.30 per tablet or capsule | $9.05 | 10/21/2026 |
| DOXEPIN 150 MG CAPSULEGeneric | $0.53 per tablet or capsule | $15.90 | 10/21/2026 |
| DOXEPIN 10 MG/ML ORAL CONCGeneric | $0.89 per mL | n/a | 10/21/2026 |
| DOXEPIN HCL 3 MG TABLETGeneric | $1.37 per tablet or capsule | $40.95 | 10/21/2026 |
| DOXEPIN HCL 6 MG TABLETGeneric | $1.41 per tablet or capsule | $42.43 | 10/21/2026 |
| DOXEPIN 5% CREAMGeneric | $7.85 per gram | n/a | 10/21/2026 |
Source: CMS NADAC, as of 2026-11-04. National average acquisition cost, not a retail quote.
Label basics
What it is used for (FDA label)
1 INDICATIONS AND USAGE Doxepin tablets are indicated for the treatment of insomnia characterized by difficulty with sleep maintenance. The clinical trials performed in support of efficacy were up to 3 months in duration. Doxepin tablets are indicated for the treatment of insomnia characterized by difficulties with sleep maintenance. ( 1 , 14 )
Common side effects (FDA label)
6 ADVERSE REACTIONS The following serious adverse reactions are discussed in greater detail in other sections of labeling: • Abnormal thinking and behavioral changes [ see Warnings and Precautions ( 5.2 ) ]. • Suicide risk and worsening of depression [ see Warnings and Precautions ( 5.3) ]. • CNS Depressant effects [ see Warnings and Precautions ( 5.4 ) ]. The most common treatment-emergent adverse reactions, reported in ≥ 2% of patients treated with doxepin tablets, and more commonly than in patients treated with placebo, were somnolence/sedation, nausea, and upper respiratory tract...
Drug interactions (from the label)
7 DRUG INTERACTIONS MAO inhibitors: Doxepin tablets should not be administered in patients on MAOIs within the past two weeks. ( 4.2 ) Cimetidine: Increases exposure to doxepin. ( 7.2 ) Alcohol: Sedative effects may be increased with doxepin. ( 7.3 , 5.4 ) CNS Depressants and Sedating Antihistamines: Sedative effects may be increased with doxepin. ( 7.4 , 5.4 ) Tolazamide: A case of severe hypoglycemia has been reported. ( 7.5 ) 7.1 Cytochrome P450 Isozymes Doxepin is primarily metabolized by hepatic cytochrome P450 isozymes CYP2C19 and CYP2D6, and to a lesser extent, by CYP1A2 and CYP2C9. Inhibitors of these isozymes may increase the exposure of doxepin. Doxepin is not an inhibitor of any...
Warnings (from the label)
5 WARNINGS AND PRECAUTIONS Need to Evaluate for comorbid diagnoses: Reevaluate if insomnia persists after 7 to 10 days of use. ( 5.1 ) Abnormal thinking, behavioral changes, complex behaviors: May include “Sleep-driving” and hallucinations. Immediately evaluate any new onset behavioral changes. ( 5.2 ) Depression: Worsening of depression or suicidal thinking may occur. Prescribe the least amount feasible to avoid intentional overdose. ( 5.3 ) CNS-depressant effects: Use can impair alertness and motor coordination. Avoid engaging in hazardous activities such as operating a motor vehicle or heavy machinery after taking drug. ( 5.4 ) Do not use with alcohol. ( 5.4 , 7.3 ) Potential additive...
Source: FDA drug label via openFDA, label effective 2025-11-07. Full label on DailyMed. Excerpts are verbatim and truncated. Read the full label and ask your pharmacist.