Tramadol: here's the fair price
This is what US pharmacies pay, on average, for tramadol. Use it to spot a fair cash price, and feel good about asking for one.
Tramadol Hcl 50 Mg Tablet
A fair cash price is usually this cost plus a dispensing fee. If your quote is many times higher, ask about a generic, another pharmacy, or a cash discount.
Ask for generic Tramadol Hcl 50 Mg Tablet. Pharmacies pay about $0.78 for 30. Ask your pharmacy for its cash price and compare it with your copay. A fair cash price is close to this cost plus a dispensing fee.
Source: CMS NADAC as of 2026-11-04. Ask your prescriber or pharmacist whether a generic is right for you.
Source: CMS NADAC weekly file as of 2026-11-04. Median across NDCs with the same description. Public domain.
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Every strength and form
| Product | Pharmacy cost | 30 count | Effective |
|---|---|---|---|
| TRAMADOL HCL 50 MG TABLETGeneric | $0.03 per tablet or capsule | $0.78 | 10/21/2026 |
| TRAMADOL HCL ER 100 MG TABLETGeneric | $0.89 per tablet or capsule | $26.70 | 10/21/2026 |
| TRAMADOL HCL 100 MG TABLETGeneric | $1.10 per tablet or capsule | $33.02 | 10/21/2026 |
| TRAMADOL HCL ER 200 MG TABLETGeneric | $1.39 per tablet or capsule | $41.61 | 10/21/2026 |
| TRAMADOL HCL ER 300 MG TABLETGeneric | $2.07 per tablet or capsule | $61.97 | 10/21/2026 |
| TRAMADOL HCL 25 MG TABLETGeneric | $3.38 per tablet or capsule | $101.37 | 10/21/2026 |
| TRAMADOL HCL ER 100 MG CAPSULEGeneric | $7.71 per tablet or capsule | $231.23 | 10/21/2026 |
| TRAMADOL HCL ER 200 MG CAPSULEGeneric | $9.85 per tablet or capsule | $295.60 | 10/21/2026 |
Source: CMS NADAC, as of 2026-11-04. National average acquisition cost, not a retail quote.
Label basics
What it is used for (FDA label)
1 INDICATIONS AND USAGE Tramadol hydrochloride extended-release tablets are indicated for the management of severe and persistent pain that requires an opioid analgesic and that cannot be adequately treated with alternative options, including immediate-release opioids. Limitations of Use • Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosages or duration, and persist over the course of therapy, [see Warnings and Precautions (5.1)], reserve opioid analgesics, including tramadol hydrochloride extended-release tablets, for use in patients for whom alternative treatment options are ineffective, not tolerated or would be otherwise inadequate to...
Common side effects (FDA label)
6 ADVERSE REACTIONS The following serious or otherwise important adverse reactions are described in greater detail, in other sections: Addiction, Abuse, and Misuse [see Warnings and Precautions (5.1)] Life-Threatening Respiratory Depression [see Warnings and Precautions (5.2)] Ultra-Rapid Metabolism of Tramadol and Other Risk Factors for Life-Threatening Respiratory Depression in Children [see Warnings and Precautions (5.6)] Neonatal Opioid Withdrawal Syndrome [see Warnings and Precautions (5.4)] Interactions with Benzodiazepines and Other CNS Depressants [see Warnings and Precautions (5.3)]...
Drug interactions (from the label)
7 DRUG INTERACTIONS Table 2 includes clinically significant drug interactions with tramadol hydrochloride extended-release tablets. Table 2: Clinically Significant Drug Interactions with Tramadol Hydrochloride Extended-Release Tablets Inhibitors of CYP2D6 Clinical Impact: The concomitant use of tramadol hydrochloride extended-release tablets and CYP2D6 inhibitors may result in an increase in the plasma concentration of tramadol and a decrease in the plasma concentration of M1, particularly when an inhibitor is added after a stable dose of tramadol hydrochloride extended-release tablets is achieved. Since M1 is a more potent µ-opioid agonist, decreased M1 exposure could result in decreased...
Warnings (from the label)
5 WARNINGS AND PRECAUTIONS Opioid Induced Hyperalgesia (OIH) and Allodynia: Opioid-Induced Hyperalgesia (OIH) occurs when an opioid analgesic paradoxically causes an increase in pain, or an increase in sensitivity to pain. If OIH is suspected, carefully consider appropriately decreasing the dose of the current opioid analgesic, or opioid rotation (5.8) Serotonin Syndrome : Potentially life-threatening condition could result from concomitant serotonergic drug administration. Discontinue tramadol hydrochloride extended-release tablets if serotonin syndrome is suspected. (5.9) Increased Risk of Seizures : Present within recommended dosage range. Risk is increased with higher than recommended...
Source: FDA drug label via openFDA, label effective 2025-11-20. Full label on DailyMed. Excerpts are verbatim and truncated. Read the full label and ask your pharmacist.