Tizanidine: here's the fair price
This is what US pharmacies pay, on average, for tizanidine. Use it to spot a fair cash price, and feel good about asking for one.
Tizanidine Hcl 2 Mg Tablet
A fair cash price is usually this cost plus a dispensing fee. If your quote is many times higher, ask about a generic, another pharmacy, or a cash discount.
Ask for generic Tizanidine Hcl 2 Mg Tablet. Pharmacies pay about $0.97 for 30. Ask your pharmacy for its cash price and compare it with your copay. A fair cash price is close to this cost plus a dispensing fee.
Source: CMS NADAC as of 2026-11-04. Ask your prescriber or pharmacist whether a generic is right for you.
Source: CMS NADAC weekly file as of 2026-11-04. Median across NDCs with the same description. Public domain.
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Every strength and form
| Product | Pharmacy cost | 30 count | Effective |
|---|---|---|---|
| TIZANIDINE HCL 2 MG TABLETGeneric | $0.03 per tablet or capsule | $0.97 | 10/21/2026 |
| TIZANIDINE HCL 4 MG TABLETGeneric | $0.03 per tablet or capsule | $1.01 | 10/21/2026 |
| TIZANIDINE HCL 2 MG CAPSULEGeneric | $0.09 per tablet or capsule | $2.69 | 10/21/2026 |
| TIZANIDINE HCL 4 MG CAPSULEGeneric | $0.10 per tablet or capsule | $3.04 | 10/21/2026 |
| TIZANIDINE HCL 6 MG CAPSULEGeneric | $0.14 per tablet or capsule | $4.31 | 10/21/2026 |
Source: CMS NADAC, as of 2026-11-04. National average acquisition cost, not a retail quote.
Label basics
What it is used for (FDA label)
1 INDICATIONS AND USAGE Tizanidine Tablets, USP is a central alpha-2-adrenergic agonist indicated for the management of spasticity. Because of the short duration of therapeutic effect, treatment with Tizanidine Tablets, USP should be reserved for those daily activities and times when relief of spasticity is most important [see Dosage and Administration(2.1) ]. Tizanidine Tablets, USP is a central alpha-2-adrenergic agonist indicated for the management of spasticity. Because of the short duration of therapeutic effect, treatment with Tizanidine Tablets, USP should be reserved for those daily activities and times when relief of spasticity is most important [ see Dosage and Administration (1)...
Common side effects (FDA label)
6 ADVERSE REACTIONS The following adverse reactions are described elsewhere in other sections of the prescribing information: • Hypotension [ see Warnings and Precautions (5.1) ] • Liver Injury [ see Warnings and Precautions (5.2) ] • Sedation [ see Warnings and Precautions (5.3) ] • Hallucinosis/Psychotic-Like Symptoms [ see Warnings and Precautions (5.4) ] • Hypersensitivity Reactions [ see Warnings and Precautions (5.6) ] The most common adverse reactions (greater than 2% of 264 patients taking tizanidine and greater than in placebo-treated patients in three multiple dose,...
Drug interactions (from the label)
7 DRUG INTERACTIONS 7.1 Fluvoxamine Concomitant use of fluvoxamine and Tizanidine Tablets, USP is contraindicated. Changes in pharmacokinetics of tizanidine when administered with fluvoxamine resulted in significantly decreased blood pressure, increased drowsiness, and increased psychomotor impairment. [ see Contraindications (4) and Clinical Pharmacology (12.3) ] 7.2 Ciprofloxacin Concomitant use of ciprofoxacin and Tizanidine Tablets, USP is contraindicated. Changes in pharmacokinetics of tizanidine when administered with ciprofloxacin resulted in significantly decreased blood pressure, increased drowsiness, and increased psychomotor impairment. [ see Contraindications (4) and Clinical...
Warnings (from the label)
5 WARNINGS AND PRECAUTIONS • Hypotension: monitor for signs and symptoms of hypotension, in particular in patients receiving concurrent antihypertensives; Tizanidine Tablets, USP should not be used with other α 2 -adrenergic agonists ( 5.1 , 7.7 ) • Risk of liver injury: monitor ALTs; discontinue Tizanidine Tablets, USP if liver injury occurs ( 5.2 ) • Sedation: Tizanidine Tablets, USP may interfere with everyday activities; sedative effects of Tizanidine Tablets, USP, alcohol, and other CNS depressants are additive ( 5.3 , 7.5 , 7.6 ) • Hallucinations: consider discontinuation of Tizanidine Tablets, USP ( 5.4 ) • Less potent inhibitors of CYP1A2: may cause hypotension, bradycardia, or...
Source: FDA drug label via openFDA, label effective 2023-11-09. Full label on DailyMed. Excerpts are verbatim and truncated. Read the full label and ask your pharmacist.