Spironolactone: here's the fair price
This is what US pharmacies pay, on average, for spironolactone. Use it to spot a fair cash price, and feel good about asking for one.
Spironolactone 25 Mg Tablet
A fair cash price is usually this cost plus a dispensing fee. If your quote is many times higher, ask about a generic, another pharmacy, or a cash discount.
Ask for generic Spironolactone 25 Mg Tablet. Pharmacies pay about $1.28 for 30. Ask your pharmacy for its cash price and compare it with your copay. A fair cash price is close to this cost plus a dispensing fee.
Source: CMS NADAC as of 2026-11-04. Ask your prescriber or pharmacist whether a generic is right for you.
Source: CMS NADAC weekly file as of 2026-11-04. Median across NDCs with the same description. Public domain.
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Every strength and form
| Product | Pharmacy cost | 30 count | Effective |
|---|---|---|---|
| SPIRONOLACTONE 25 MG TABLETGeneric | $0.04 per tablet or capsule | $1.28 | 10/21/2026 |
| SPIRONOLACTONE 50 MG TABLETGeneric | $0.08 per tablet or capsule | $2.50 | 10/21/2026 |
| SPIRONOLACTONE 100 MG TABLETGeneric | $0.16 per tablet or capsule | $4.92 | 10/21/2026 |
| SPIRONOLACTONE 25 MG/5 ML SUSPGeneric | $1.85 per mL | n/a | 10/21/2026 |
Source: CMS NADAC, as of 2026-11-04. National average acquisition cost, not a retail quote.
Label basics
What it is used for (FDA label)
1 INDICATIONS AND USAGE Spironolactone tablets are an aldosterone antagonist indicated for: The treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema, and to reduce the need for hospitalization for heart failure ( 1.1 ). Use as an add-on therapy for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions ( 1.2 ). The management of edema in adult patients who are cirrhotic when edema is not responsive to fluid and sodium restrictions and in the setting of nephrotic syndrome when treatment of the underlying...
Common side effects (FDA label)
6 ADVERSE REACTIONS The following clinically significant adverse reactions are described elsewhere in the labeling: Hyperkalemia [ see Warnings and Precautions (5.1) ] Hypotension and Worsening Renal Function [ see Warnings and Precautions (5.2) ] Electrolyte and Metabolic Abnormalities [ see Warnings and Precautions (5.3) ] Gynecomastia [ see Warnings and Precautions (5.4) ] Impaired neurological function/ coma in patients with hepatic impairment, cirrhosis and ascites [ see Use in Specific Populations (8.7) ] The following adverse reactions associated with the use of spironolactone were...
Drug interactions (from the label)
7 DRUG INTERACTIONS Agents increasing serum potassium: Concomitant administration can lead to hyperkalemia ( 5.1 , 7.1 ). Lithium: Increased risk of lithium toxicity ( 7.2 ). NSAIDs: May reduce the diuretic, natriuretic and antihypertensive effect of spironolactone tablets ( 7.3 ). Digoxin: Spironolactone tablets can interfere with radioimmunologic assays of digoxin exposure ( 7.4 ). Cholestyramine: Hyperkalemic metabolic acidosis has been reported with concomitant use ( 7.5 ). Acetylsalicylic Acid (ASA): ASA may reduce the efficacy of spironolactone tablets ( 7.6 ). Abiraterone: May increase prostate-specific antigen (PSA) levels ( 7.7 ). Mitotane: Avoid concomitant use of spironolactone...
Warnings (from the label)
5 WARNINGS AND PRECAUTIONS Hyperkalemia: Monitor serum potassium within one week of initiation and regularly thereafter (5.1). Hypotension and Worsening Renal Function: Monitor volume status and renal function periodically (5.2). Electrolyte and Metabolic Abnormalities: Monitor serum electrolytes, uric acid and blood glucose periodically (5.3). Gynecomastia: Spironolactone tablets can cause gynecomastia (5.4). 5.1 Hyperkalemia Spironolactone tablets can cause hyperkalemia. This risk is increased by impaired renal function or concomitant potassium supplementation, potassium-containing salt substitutes or drugs that increase potassium, such as angiotensin converting enzyme inhibitors and...
Source: FDA drug label via openFDA, label effective 2026-09-09. Full label on DailyMed. Excerpts are verbatim and truncated. Read the full label and ask your pharmacist.