Promethazine: here's the fair price
This is what US pharmacies pay, on average, for promethazine. Use it to spot a fair cash price, and feel good about asking for one.
Promethazine 25 Mg Tablet
A fair cash price is usually this cost plus a dispensing fee. If your quote is many times higher, ask about a generic, another pharmacy, or a cash discount.
Ask for generic Promethazine 25 Mg Tablet. Pharmacies pay about $1.37 for 30. Ask your pharmacy for its cash price and compare it with your copay. A fair cash price is close to this cost plus a dispensing fee.
Source: CMS NADAC as of 2026-11-04. Ask your prescriber or pharmacist whether a generic is right for you.
Source: CMS NADAC weekly file as of 2026-11-04. Median across NDCs with the same description. Public domain.
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Every strength and form
| Product | Pharmacy cost | 30 count | Effective |
|---|---|---|---|
| PROMETHAZINE 6.25 MG/5 ML SOLNGeneric | $0.04 per mL | n/a | 10/21/2026 |
| PROMETHAZINE 6.25 MG/5 ML SYRPGeneric | $0.04 per mL | n/a | 10/21/2026 |
| PROMETHAZINE 25 MG TABLETGeneric | $0.05 per tablet or capsule | $1.37 | 10/21/2026 |
| PROMETHAZINE 12.5 MG TABLETGeneric | $0.05 per tablet or capsule | $1.63 | 10/21/2026 |
| PROMETHAZINE 50 MG TABLETGeneric | $0.09 per tablet or capsule | $2.56 | 10/21/2026 |
| PROMETHAZINE 25 MG/ML AMPULGeneric | $1.38 per mL | n/a | 10/21/2026 |
| PROMETHAZINE 25 MG/ML VIALGeneric | $1.75 per mL | n/a | 10/21/2026 |
| PROMETHAZINE 25 MG SUPPOSITORYGeneric | $1.93 per tablet or capsule | $57.76 | 10/21/2026 |
| PROMETHAZINE 12.5 MG SUPPOSGeneric | $1.98 per tablet or capsule | $59.28 | 10/21/2026 |
| PROMETHAZINE 50 MG/ML AMPULGeneric | $2.34 per mL | n/a | 05/20/2026 |
Source: CMS NADAC, as of 2026-11-04. National average acquisition cost, not a retail quote.
Label basics
What it is used for (FDA label)
INDICATIONS AND USAGE Promethazine Hydrochloride Tablets are useful for: Perennial and seasonal allergic rhinitis. Vasomotor rhinitis. Allergic conjunctivitis due to inhalant allergens and foods. Mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Amelioration of allergic reactions to blood or plasma. Dermographism. Anaphylactic reactions as adjunctive therapy to epinephrine and other standard measures after the acute manifestations have been controlled. Preoperative, postoperative and obstetric sedation. Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery. Therapy adjunctive to meperidine or other analgesics for...
Common side effects (FDA label)
ADVERSE REACTIONS Central Nervous System: Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported. Cardiovascular: Increased or decreased blood pressure, tachycardia, bradycardia, faintness. Dermatologic: Dermatitis,...
Warnings (from the label)
WARNINGS Promethazine hydrochloride should not be used in pediatric patients less than 2 years of age because of the potential for fatal respiratory depression. Postmarketing cases of respiratory depression, including fatalities, have been reported with use of promethazine hydrochloride in pediatric patients less than 2 years of age. A wide range of weight-based doses of promethazine hydrochloride have resulted in respiratory depression in these patients. Caution should be exercised when administering promethazine hydrochloride to pediatric patients 2 years of age and older. It is recommended that the lowest effective dose of promethazine hydrochloride be used in pediatric patients 2 years...
Source: FDA drug label via openFDA, label effective 2024-10-30. Full label on DailyMed. Excerpts are verbatim and truncated. Read the full label and ask your pharmacist.