Ondansetron: here's the fair price
This is what US pharmacies pay, on average, for ondansetron. Use it to spot a fair cash price, and feel good about asking for one.
Ondansetron Hcl 4 Mg Tablet
A fair cash price is usually this cost plus a dispensing fee. If your quote is many times higher, ask about a generic, another pharmacy, or a cash discount.
Ask for generic Ondansetron Hcl 4 Mg Tablet. Pharmacies pay about $1.74 for 30. Ask your pharmacy for its cash price and compare it with your copay. A fair cash price is close to this cost plus a dispensing fee.
Source: CMS NADAC as of 2026-11-04. Ask your prescriber or pharmacist whether a generic is right for you.
Source: CMS NADAC weekly file as of 2026-11-04. Median across NDCs with the same description. Public domain.
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Every strength and form
| Product | Pharmacy cost | 30 count | Effective |
|---|---|---|---|
| ONDANSETRON HCL 4 MG TABLETGeneric | $0.06 per tablet or capsule | $1.74 | 10/21/2026 |
| ONDANSETRON HCL 8 MG TABLETGeneric | $0.08 per tablet or capsule | $2.30 | 10/21/2026 |
| ONDANSETRON ODT 4 MG TABLETGeneric | $0.12 per tablet or capsule | $3.69 | 10/21/2026 |
| ONDANSETRON HCL 4 MG/2 ML VIALGeneric | $0.18 per mL | n/a | 10/21/2026 |
| ONDANSETRON ODT 8 MG TABLETGeneric | $0.18 per tablet or capsule | $5.39 | 10/21/2026 |
| ONDANSETRON 40 MG/20 ML VIALGeneric | $0.19 per mL | n/a | 10/21/2026 |
| ONDANSETRON 4 MG/5 ML SOLUTIONGeneric | $0.29 per mL | n/a | 10/21/2026 |
| ONDANSETRON 4 MG/5 ML SOLUTION CUPGeneric | $0.29 per mL | n/a | 10/21/2026 |
Source: CMS NADAC, as of 2026-11-04. National average acquisition cost, not a retail quote.
Label basics
What it is used for (FDA label)
1 INDICATIONS AND USAGE Ondansetron is indicated for the prevention of nausea and vomiting associated with: • highly emetogenic cancer chemotherapy, including cisplatin greater than or equal to 50 mg/m 2 • initial and repeat courses of moderately emetogenic cancer chemotherapy • radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen Ondansetron is also indicated for the prevention of postoperative nausea and/or vomiting. Ondansetron is a 5-HT 3 receptor antagonist indicated for the prevention of: • nausea and vomiting associated with highly emetogenic cancer chemotherapy, including cisplatin greater than...
Common side effects (FDA label)
6 ADVERSE REACTIONS The following clinically significant adverse reactions are described elsewhere in the labeling: • Hypersensitivity Reactions [see Warnings and Precautions ( 5.1 )] • QT Prolongation [see Warnings and Precautions ( 5.2 )] • Serotonin Syndrome [see Warnings and Precautions ( 5.3 )] • Myocardial Ischemia [see Warnings and Precautions ( 5.4 )] • Masking of Progressive Ileus and Gastric Distension [see Warnings and Precautions ( 5.5 )] The most common adverse reactions in adults for the: • prevention of chemotherapy-induced (≥5%) are: headache, malaise/fatigue, constipation,...
Drug interactions (from the label)
7 DRUG INTERACTIONS 7.1 Serotonergic Drugs Serotonin syndrome (including altered mental status, autonomic instability, and neuromuscular symptoms) has been described following the concomitant use of 5-HT 3 receptor antagonists and other serotonergic drugs, including SSRIs and SNRIs. Monitor for the emergence of serotonin syndrome. If symptoms occur, discontinue ondansetron and initiate supportive treatment [see Warnings and Precautions ( 5.3 )] . 7.2 Drugs Affecting Cytochrome P-450 Enzymes Ondansetron does not itself appear to induce or inhibit the cytochrome P‑450 drug‑metabolizing enzyme system of the liver [see Clinical Pharmacology ( 12.3 )] . Because ondansetron is metabolized by...
Warnings (from the label)
5 WARNINGS AND PRECAUTIONS • Hypersensitivity Reactions Including Anaphylaxis and Bronchospasm : Discontinue ondansetron if suspected. Monitor and treat promptly per standard of care until signs and symptoms resolve. ( 5.1 ) • QT Interval Prolongation and Torsade de Pointes : Avoid in patients with congenital long QT syndrome; monitor with electrocardiograms (ECGs) if concomitant electrolyte abnormalities, cardiac failure or arrhythmias, or use of other QT prolonging drugs. ( 5.2 ) • Serotonin Syndrome : Reported with 5-HT 3 receptor antagonists alone but particularly with concomitant use of serotonergic drugs. If such symptoms occur, discontinue ondansetron and initiate supportive...
Source: FDA drug label via openFDA, label effective 2026-07-29. Full label on DailyMed. Excerpts are verbatim and truncated. Read the full label and ask your pharmacist.