Methylprednisolone: here's the fair price
This is what US pharmacies pay, on average, for methylprednisolone. Use it to spot a fair cash price, and feel good about asking for one.
Methylprednisolone 4 Mg Tablet
A fair cash price is usually this cost plus a dispensing fee. If your quote is many times higher, ask about a generic, another pharmacy, or a cash discount.
Ask for generic Methylprednisolone 4 Mg Tablet. Pharmacies pay about $3.49 for 30. Ask your pharmacy for its cash price and compare it with your copay. A fair cash price is close to this cost plus a dispensing fee.
Source: CMS NADAC as of 2026-11-04. Ask your prescriber or pharmacist whether a generic is right for you.
Source: CMS NADAC weekly file as of 2026-11-04. Median across NDCs with the same description. Public domain.
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Every strength and form
| Product | Pharmacy cost | 30 count | Effective |
|---|---|---|---|
| METHYLPREDNISOLONE 4 MG TABLETGeneric | $0.12 per tablet or capsule | $3.49 | 10/21/2026 |
| METHYLPREDNISOLONE 4 MG DOSEPKGeneric | $0.14 per tablet or capsule | $4.32 | 10/21/2026 |
| METHYLPREDNISOLONE 8 MG TABLETGeneric | $0.92 per tablet or capsule | $27.70 | 10/21/2026 |
| METHYLPREDNISOLONE 16 MG TABGeneric | $1.48 per tablet or capsule | $44.28 | 10/21/2026 |
| METHYLPREDNISOLONE 32 MG TABGeneric | $2.55 per tablet or capsule | $76.55 | 10/21/2026 |
| METHYLPREDNISOLONE SS 125 MGGeneric | $3.27 per tablet or capsule | $97.97 | 10/21/2026 |
| METHYLPREDNISOLONE 400 MG/10 MLGeneric | $5.57 per mL | n/a | 10/21/2026 |
| METHYLPREDNISOLONE 40 MG/ML VLGeneric | $7.49 per mL | n/a | 10/21/2026 |
| METHYLPREDNISOLONE 80 MG/ML VLGeneric | $11.92 per mL | n/a | 07/22/2026 |
Source: CMS NADAC, as of 2026-11-04. National average acquisition cost, not a retail quote.
Label basics
What it is used for (FDA label)
INDICATIONS AND USAGE Methylprednisolone tablets are indicated in the following conditions: 1. Endocrine Disorders Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance). Congenital adrenal hyperplasia Nonsuppurative thyroiditis Hypercalcemia associated with cancer 2. Rheumatic Disorders As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may...
Common side effects (FDA label)
ADVERSE REACTIONS Fluid and Electrolyte Disturbances Sodium retention Congestive heart failure in susceptible patients Hypertension Fluid retention Potassium loss Hypokalemic alkalosis Musculoskeletal Muscle weakness Loss of muscle mass Steroid myopathy Osteoporosis Tendon rupture, particularly of the Achilles tendon Vertebral compression fractures Aseptic necrosis of femoral and humeral heads Pathologic fracture of long bones Gastrointestinal Peptic ulcer with possible perforation and hemorrhage Pancreatitis Abdominal distention Ulcerative esophagitis Increases in alanine transaminase (ALT,...
Drug interactions (from the label)
DRUG INTERACTIONS The pharmacokinetic interactions listed below are potentially clinically important. Mutual inhibition of metabolism occurs with concurrent use of cyclosporin and methylprednisolone; therefore, it is possible that adverse events associated with the individual use of either drug may be more apt to occur. Convulsions have been reported with concurrent use of methylprednisolone and cyclosporin. Drugs that induce hepatic enzymes such as phenobarbital, phenytoin and rifampin may increase the clearance of methylprednisolone and may require increases in methylprednisolone dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole may inhibit the metabolism...
Warnings (from the label)
WARNINGS In patients on corticosteroid therapy subjected to unusual stress, increased dosage of rapidly acting corticosteroids before, during, and after the stressful situation is indicated. Corticosteroids may mask some signs of infection, and new infections may appear during their use. Infections with any pathogen including viral, bacterial, fungal, protozoan or helminthic infections, in any location of the body, may be associated with the use of corticosteroids alone or in combination with other immunosuppressive agents that affect cellular immunity, humoral immunity, or neutrophil function. 1 These infections may be mild, but can be severe and at times fatal. With increasing doses of...
Source: FDA drug label via openFDA, label effective 2024-04-12. Full label on DailyMed. Excerpts are verbatim and truncated. Read the full label and ask your pharmacist.