Levothyroxine: here's the fair price
This is what US pharmacies pay, on average, for levothyroxine. Use it to spot a fair cash price, and feel good about asking for one.
Levothyroxine 25 Mcg Tablet
A fair cash price is usually this cost plus a dispensing fee. If your quote is many times higher, ask about a generic, another pharmacy, or a cash discount.
Ask for generic Levothyroxine 25 Mcg Tablet. Pharmacies pay about $1.06 for 30. Ask your pharmacy for its cash price and compare it with your copay. A fair cash price is close to this cost plus a dispensing fee.
Source: CMS NADAC as of 2026-11-04. Ask your prescriber or pharmacist whether a generic is right for you.
Source: CMS NADAC weekly file as of 2026-11-04. Median across NDCs with the same description. Public domain.
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Every strength and form
| Product | Pharmacy cost | 30 count | Effective |
|---|---|---|---|
| LEVOTHYROXINE 25 MCG TABLETGeneric | $0.04 per tablet or capsule | $1.06 | 10/21/2026 |
| LEVOTHYROXINE 50 MCG TABLETGeneric | $0.04 per tablet or capsule | $1.20 | 10/21/2026 |
| LEVOTHYROXINE 75 MCG TABLETGeneric | $0.05 per tablet or capsule | $1.40 | 10/21/2026 |
| LEVOTHYROXINE 88 MCG TABLETGeneric | $0.05 per tablet or capsule | $1.43 | 10/21/2026 |
| LEVOTHYROXINE 100 MCG TABLETGeneric | $0.05 per tablet or capsule | $1.49 | 10/21/2026 |
| LEVOTHYROXINE 150 MCG TABLETGeneric | $0.06 per tablet or capsule | $1.70 | 10/21/2026 |
| LEVOTHYROXINE 125 MCG TABLETGeneric | $0.06 per tablet or capsule | $1.73 | 10/21/2026 |
| LEVOTHYROXINE 112 MCG TABLETGeneric | $0.06 per tablet or capsule | $1.74 | 10/21/2026 |
| LEVOTHYROXINE 137 MCG TABLETGeneric | $0.06 per tablet or capsule | $1.90 | 10/21/2026 |
| LEVOTHYROXINE 175 MCG TABLETGeneric | $0.07 per tablet or capsule | $2.24 | 10/21/2026 |
| LEVOTHYROXINE 200 MCG TABLETGeneric | $0.08 per tablet or capsule | $2.55 | 10/21/2026 |
| LEVOTHYROXINE 300 MCG TABLETGeneric | $0.11 per tablet or capsule | $3.28 | 10/21/2026 |
Source: CMS NADAC, as of 2026-11-04. National average acquisition cost, not a retail quote.
Label basics
What it is used for (FDA label)
1 INDICATIONS AND USAGE Hypothyroidism Levothyroxine sodium tablets are indicated in adult and pediatric patients, including neonates, as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism. Pituitary Thyrotropin (Thyroid‑Stimulating Hormone, TSH) Suppression Levothyroxine sodium tablets are indicated in adult and pediatric patients, including neonates, as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer. Limitations of Use Levothyroxine sodium tablets are not indicated for suppression of benign thyroid nodules and nontoxic diffuse...
Common side effects (FDA label)
6 ADVERSE REACTIONS Adverse reactions associated with levothyroxine sodium therapy are primarily those of hyperthyroidism due to therapeutic overdosage [see Warnings and Precautions (5) and Overdosage (10) ]. They include the following: General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia Musculoskeletal: tremors, muscle weakness, muscle spasm Cardiovascular: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart...
Drug interactions (from the label)
7 DRUG INTERACTIONS See full prescribing information for drugs that affect thyroid hormone pharmacokinetics and metabolism (e.g., absorption, synthesis, secretion, catabolism, protein binding, and target tissue response) and may alter the therapeutic response to levothyroxine sodium. (7) 7.1 Drugs Known to Affect Thyroid Hormone Pharmacokinetics Many drugs can exert effects on thyroid hormone pharmacokinetics and metabolism (e.g., absorption, synthesis, secretion, catabolism, protein binding, and target tissue response) and may alter the therapeutic response to levothyroxine sodium (Tables 5 to 8). Table 5. Drugs That May Decrease T4 Absorption (Hypothyroidism) Potential impact: Concurrent...
Warnings (from the label)
5 WARNINGS AND PRECAUTIONS Serious risks related to overtreatment or undertreatment with levothyroxine sodium tablets: Titrate the dose of levothyroxine sodium carefully and monitor response to titration. (5.1) Cardiac adverse reactions in the elderly and in patients with underlying cardiovascular disease: Initiate levothyroxine sodium at less than the full replacement dose because of the increased risk of cardiac adverse reactions, including atrial fibrillation. (2.3 , 5.2 , 8.5) Myxedema coma: Do not use oral thyroid hormone drug products to treat myxedema coma. (5.3) Acute adrenal crisis in patients with concomitant adrenal insufficiency: Treat with replacement glucocorticoids prior to...
Source: FDA drug label via openFDA, label effective 2026-03-24. Full label on DailyMed. Excerpts are verbatim and truncated. Read the full label and ask your pharmacist.