Fluoxetine: here's the fair price
This is what US pharmacies pay, on average, for fluoxetine. Use it to spot a fair cash price, and feel good about asking for one.
Fluoxetine Hcl 20 Mg Capsule
A fair cash price is usually this cost plus a dispensing fee. If your quote is many times higher, ask about a generic, another pharmacy, or a cash discount.
Ask for generic Fluoxetine Hcl 20 Mg Capsule. Pharmacies pay about $0.88 for 30. Ask your pharmacy for its cash price and compare it with your copay. A fair cash price is close to this cost plus a dispensing fee.
Source: CMS NADAC as of 2026-11-04. Ask your prescriber or pharmacist whether a generic is right for you.
Source: CMS NADAC weekly file as of 2026-11-04. Median across NDCs with the same description. Public domain.
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Every strength and form
| Product | Pharmacy cost | 30 count | Effective |
|---|---|---|---|
| FLUOXETINE HCL 20 MG CAPSULEGeneric | $0.03 per tablet or capsule | $0.88 | 10/21/2026 |
| FLUOXETINE HCL 10 MG CAPSULEGeneric | $0.03 per tablet or capsule | $1.02 | 10/21/2026 |
| FLUOXETINE HCL 40 MG CAPSULEGeneric | $0.05 per tablet or capsule | $1.62 | 10/21/2026 |
| FLUOXETINE HCL 10 MG TABLETGeneric | $0.06 per tablet or capsule | $1.94 | 10/21/2026 |
| FLUOXETINE HCL 20 MG TABLETGeneric | $0.10 per tablet or capsule | $2.91 | 10/21/2026 |
| FLUOXETINE HCL 60 MG TABLETGeneric | $0.18 per tablet or capsule | $5.54 | 10/21/2026 |
| FLUOXETINE 20 MG/5 ML SOLUTIONGeneric | $0.22 per mL | n/a | 10/21/2026 |
| FLUOXETINE DR 90 MG CAPSULEGeneric | $30.55 per tablet or capsule | $916.50 | 10/21/2026 |
Source: CMS NADAC, as of 2026-11-04. National average acquisition cost, not a retail quote.
Label basics
What it is used for (FDA label)
1 INDICATIONS & USAGE Fluoxetine capsules are indicated for the treatment of: • Acute and maintenance treatment of Major Depressive Disorder [ see Clinical Studies (14.1)]. • Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [ see Clinical Studies (14.2 )]. • Acute and maintenance treatment of binge-eating and vomiting behaviors in patients with moderate to severe Bulimia Nervosa [ see Clinical Studies (14.3 )]. • Acute treatment of Panic Disorder, with or without agoraphobia [ see Clinical Studies (14.4 ) ]. Fluoxetine capsules and Olanzapine in Combination is indicated for the treatment of: • Acute treatment of depressive...
Common side effects (FDA label)
6 ADVERSE REACTIONS The following adverse reactions are discussed in more detail in other sections of the labeling: • Suicidal Thoughts and Behaviors in Children, Adolescents, and Young Adults [ see Boxed Warning and Warnings and Precautions (5.1)] • Serotonin Syndrome [ see Warnings and Precautions (5.2)] • Allergic Reactions and Rash [ see Warnings and Precautions (5.3) ] • Screening Patients for Bipolar Disorder and Monitoring for Mania/Hypomania [ see Warnings and Precautions (5.4)] • Seizures [ see Warnings and Precautions (5.5)] • Altered Appetite and Weight [ see Warnings and...
Drug interactions (from the label)
7 DRUG INTERACTIONS As with all drugs, the potential for interaction by a variety of mechanisms (e.g., pharmacodynamic, pharmacokinetic drug inhibition or enhancement, etc.) is a possibility. • Monoamine Oxidase Inhibitors (MAOIs): ( 2.9 , 2.10 , 4.1 , 5.2 ) • Drugs Metabolized by CYP2D6: Fluoxetine is a potent inhibitor of CYP2D6 enzyme pathway ( 7.7 ) • Tricyclic Antidepressants (TCAs): Monitor TCA levels during coadministration with fluoxetine or when fluoxetine has been recently discontinued ( 5.2 , 7.7 ) • CNS Acting Drugs: Caution should be used when taken in combination with other centrally acting drugs ( 7.2 ) • Benzodiazepines: Diazepam - increased t ½ , alprazolam - further...
Warnings (from the label)
5 WARNINGS AND PRECAUTIONS When using fluoxetine and olanzapine in combination, also refer to the Warnings and Precautions section of the package insert for Symbyax. • Suicidal Thoughts and Behaviors in Children, Adolescents, and Young Adults: Monitor for clinical worsening and suicidal thinking and behavior ( 5.1 ) • Serotonin Syndrome: Serotonin syndrome has been reported with SSRIs and SNRIs, including fluoxetine, both when taken alone, but especially when co-administered with other serotonergic agents. If such symptoms occur, discontinue fluoxetine and serotonergic agents and initiate supportive treatment. If concomitant use of fluoxetine with other serotonergic drugs is clinically...
Source: FDA drug label via openFDA, label effective 2024-07-12. Full label on DailyMed. Excerpts are verbatim and truncated. Read the full label and ask your pharmacist.