Diphenhydramine: here's the fair price
This is what US pharmacies pay, on average, for diphenhydramine. Use it to spot a fair cash price, and feel good about asking for one.
Diphenhydramine 50 Mg Capsule
A fair cash price is usually this cost plus a dispensing fee. If your quote is many times higher, ask about a generic, another pharmacy, or a cash discount.
Ask for generic Diphenhydramine 50 Mg Capsule. Pharmacies pay about $0.83 for 30. Ask your pharmacy for its cash price and compare it with your copay. A fair cash price is close to this cost plus a dispensing fee.
Source: CMS NADAC as of 2026-11-04. Ask your prescriber or pharmacist whether a generic is right for you.
Source: CMS NADAC weekly file as of 2026-11-04. Median across NDCs with the same description. Public domain.
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Every strength and form
| Product | Pharmacy cost | 30 count | Effective |
|---|---|---|---|
| DIPHENHYDRAMINE 12.5 MG/5 MLGeneric | $0.02 per mL | n/a | 10/21/2026 |
| DIPHENHYDRAMINE 50 MG CAPSULEGeneric | $0.03 per tablet or capsule | $0.83 | 10/21/2026 |
| DIPHENHYDRAMINE 25 MG TABLETGeneric | $0.04 per tablet or capsule | $1.08 | 10/21/2026 |
| DIPHENHYDRAMINE 25 MG CAPSULEGeneric | $0.05 per tablet or capsule | $1.56 | 10/21/2026 |
| DIPHENHYDRAMINE 50 MG/ML VIALGeneric | $0.87 per mL | n/a | 10/21/2026 |
Source: CMS NADAC, as of 2026-11-04. National average acquisition cost, not a retail quote.
Label basics
What it is used for (FDA label)
Uses temporarily relieves these symptoms due to hay fever or other respiratory allergies: ■ sneezing ■ itching of the nose or throat ■ runny nose ■ itchy watery eyes ■temporarily relieves these symptoms due to the common cold: ■ sneezing ■ runny nose
Warnings (from the label)
Warnings Do not use ■ with any other product containing diphenhydramine, even one used on skin ■ to make a child sleepy Ask a doctor before use if the child has ■ glaucoma ■ a breathing problem such as chronic bronchitis
Source: FDA drug label via openFDA, label effective 2025-01-22. Full label on DailyMed. Excerpts are verbatim and truncated. Read the full label and ask your pharmacist.