Bupropion: here's the fair price
This is what US pharmacies pay, on average, for bupropion. Use it to spot a fair cash price, and feel good about asking for one.
Bupropion Hcl Sr 100 Mg Tablet
A fair cash price is usually this cost plus a dispensing fee. If your quote is many times higher, ask about a generic, another pharmacy, or a cash discount.
Ask for generic Bupropion Hcl Sr 100 Mg Tablet. Pharmacies pay about $2.11 for 30. Ask your pharmacy for its cash price and compare it with your copay. A fair cash price is close to this cost plus a dispensing fee.
Source: CMS NADAC as of 2026-11-04. Ask your prescriber or pharmacist whether a generic is right for you.
Source: CMS NADAC weekly file as of 2026-11-04. Median across NDCs with the same description. Public domain.
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Every strength and form
| Product | Pharmacy cost | 30 count | Effective |
|---|---|---|---|
| BUPROPION HCL SR 100 MG TABLETGeneric | $0.07 per tablet or capsule | $2.11 | 10/21/2026 |
| BUPROPION HCL XL 150 MG TABLETGeneric | $0.08 per tablet or capsule | $2.35 | 10/21/2026 |
| BUPROPION HCL SR 150 MG TABLETGeneric | $0.08 per tablet or capsule | $2.43 | 10/21/2026 |
| BUPROPION HCL 75 MG TABLETGeneric | $0.10 per tablet or capsule | $2.86 | 10/21/2026 |
| BUPROPION HCL XL 300 MG TABLETGeneric | $0.10 per tablet or capsule | $2.94 | 10/21/2026 |
| BUPROPION HCL SR 200 MG TABLETGeneric | $0.10 per tablet or capsule | $3.11 | 10/21/2026 |
| BUPROPION HCL 100 MG TABLETGeneric | $0.12 per tablet or capsule | $3.48 | 10/21/2026 |
| BUPROPION HCL XL 450 MG TABLETGeneric | $8.10 per tablet or capsule | $242.95 | 10/21/2026 |
Source: CMS NADAC, as of 2026-11-04. National average acquisition cost, not a retail quote.
Label basics
What it is used for (FDA label)
1 INDICATIONS AND USAGE Bupropion hydrochloride extended-release tablets (XL) are an aminoketone antidepressant, indicated for: treatment of major depressive disorder (MDD) (1.1) prevention of seasonal affective disorder (SAD) ( 1.2) 1.1 Major Depressive Disorder (MDD) Bupropion hydrochloride extended-release tablets (XL) are indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual (DSM). The efficacy of the immediate-release formulation of bupropion was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult patients with MDD. The efficacy of the sustained-release formulation of...
Common side effects (FDA label)
6 ADVERSE REACTIONS The following adverse reactions are discussed in greater detail in other sections of the labeling: Suicidal thoughts and behaviors in children, adolescents, and young adults [see Warnings and Precautions (5.1) ] Neuropsychiatric adverse events and suicide risk in smoking cessation treatment [see Warnings and Precautions (5.2) ] Seizure [see Warnings and Precautions (5.3) ] Hypertension [see Warnings and Precautions (5.4) ] Activation of mania or hypomania [see Warnings and Precautions (5.5) ] Psychosis and other neuropsychiatric events [see Warnings and Precautions (5.6) ]...
Drug interactions (from the label)
7 DRUG INTERACTIONS CYP2B6 inducers: Dose increase may be necessary if coadministered with CYP2B6 inducers (e.g., ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, and phenytoin) based on clinical exposure, but should not exceed the maximum recommended dose. ( 7.1 ) Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). Consider dose reduction when using with bupropion. ( 7.2...
Warnings (from the label)
5 WARNINGS AND PRECAUTIONS Neuropsychiatric Adverse Events During Smoking Cessation: Postmarketing reports of serious or clinically significant neuropsychiatric adverse events have included changes in mood (including depression and mania), psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, agitation, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide. Observe patients attempting to quit smoking with bupropion hydrochloride extended-release tablets (XL) for the occurrence of such symptoms and instruct them to discontinue bupropion hydrochloride extended-release (XL) tablets and contact a healthcare provider if they...
Source: FDA drug label via openFDA, label effective 2025-11-25. Full label on DailyMed. Excerpts are verbatim and truncated. Read the full label and ask your pharmacist.